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| Role | Insider | Date | Transaction | Value | Shares |
|---|---|---|---|---|---|
| 10% Owner | ORBIMED ADVISORS LLC | Apr 10, 2025 | Sell | $23.52M | 56,004,974 |
| 10% Owner | ORBIMED ADVISORS LLC | Apr 10, 2025 | Sell | $7.19M | 17,109,618 |
| Chief Commercial Officer | Brandt Kevin D | Nov 17, 2023 | Buy | $49.84K | 41,670 |
| CFO | Neils Scott C | Jan 18, 2023 | Sell | $5.28K | 8,673 |
| CEO | Browne Sean E | Oct 19, 2022 | Sell | $31.82K | 51,100 |
| CEO | Browne Sean E | Oct 18, 2022 | Sell | $54.01K | 80,000 |
| Director | Vizirgianakis Stavros G. | Oct 7, 2022 | Buy | $1.09M | 2,264,861 |
| Director | Vizirgianakis Stavros G. | Oct 7, 2022 | Buy | $0 | 566,214 |
| Chief Commercial Officer | Brandt Kevin D | Aug 17, 2022 | Sell | $2.05K | 4,300 |
| CFO | Neils Scott C | Aug 17, 2022 | Sell | $605.03 | 1,270 |
| Chief Commercial Officer | Brandt Kevin D | Aug 16, 2022 | Sell | $9.17K | 18,700 |
| CFO | Neils Scott C | Aug 16, 2022 | Sell | $2.46K | 5,100 |
| Director | Rizzo Matthew | Feb 14, 2018 | Buy | $4.35M | 603,687 |
| Director | Eggenberg Michael | Feb 14, 2018 | Buy | $4.35M | 603,687 |
| Director | ORBIMED ADVISORS LLC | Feb 14, 2018 | Buy | $4.35M | 603,687 |
| Director | Rizzo Matthew | Feb 14, 2018 | Buy | $2.46M | 342,132 |
| Director | Eggenberg Michael | Feb 14, 2018 | Buy | $2.46M | 342,132 |
| Director | ORBIMED ADVISORS LLC | Feb 14, 2018 | Buy | $2.46M | 342,132 |
Open-market purchases and sales reported on SEC form 4 over the last 10years. Awards, option exercises, gifts and other non-market form 4 activity are excluded. Chart markers group a day's filings by direction; the table lists each filing.