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| Role | Insider | Date | Transaction | Value | Shares |
|---|---|---|---|---|---|
| Senior VP, Finance and PAO | Nemec Sarah | Dec 5, 2025 | Buy | $575.88 | 125 |
| CEO | Quinn William P. | Dec 5, 2025 | Buy | $575.88 | 125 |
| CEO | Quinn William P. | Jun 6, 2025 | Buy | $686.5 | 125 |
| Senior VP, Finance and PAO | Nemec Sarah | Jun 6, 2025 | Buy | $686.5 | 125 |
| CEO | Quinn William P. | Dec 16, 2024 | Buy | $1.24K | 2,500 |
| Senior VP, Finance and PAO | Nemec Sarah | Dec 16, 2024 | Buy | $1.24K | 2,500 |
| CEO | Quinn William P. | Jun 6, 2024 | Buy | $1.59K | 2,500 |
| Senior VP, Finance and PAO | Nemec Sarah | Jun 6, 2024 | Buy | $1.59K | 2,500 |
| CFO | Quinn William P. | Dec 12, 2023 | Buy | $7.13K | 7,500 |
| Chief Business Officer | Yonehiro Grant | Dec 6, 2023 | Buy | $1.96K | 2,500 |
| CEO | Schatzman Randall C | Dec 6, 2023 | Buy | $1.96K | 2,500 |
| CFO | Quinn William P. | Dec 6, 2023 | Buy | $1.96K | 2,500 |
| Chief Medical Officer | Perez Edith A. | Dec 6, 2023 | Buy | $1.96K | 2,500 |
| Director | ENGLEMAN EDGAR | Nov 30, 2023 | Sell | $92.8K | 108,145 |
| Director | ENGLEMAN EDGAR | Nov 30, 2023 | Sell | $12.81K | 14,934 |
| Director | ENGLEMAN EDGAR | Nov 29, 2023 | Sell | $20.54K | 22,674 |
| Director | ENGLEMAN EDGAR | Nov 29, 2023 | Sell | $2.84K | 3,131 |
| Director | ENGLEMAN EDGAR | Nov 21, 2023 | Sell | $1.54K | 1,707 |
| 10% Owner | Vivo Capital VIII, LLC | Nov 21, 2023 | Sell | $1.54K | 1,707 |
| Director | ENGLEMAN EDGAR | Nov 21, 2023 | Sell | $212.73 | 236 |
| 10% Owner | Vivo Capital VIII, LLC | Nov 21, 2023 | Sell | $212.4 | 236 |
| 10% Owner | Vivo Capital VIII, LLC | Nov 21, 2023 | Sell | $1.31K | 1,457 |
| Director | ENGLEMAN EDGAR | Nov 20, 2023 | Sell | $25.27K | 27,465 |
| Director | ENGLEMAN EDGAR | Nov 20, 2023 | Sell | $3.49K | 3,792 |
| 10% Owner | Vivo Capital VIII, LLC | Nov 20, 2023 | Sell | $25.27K | 27,465 |
Open-market purchases and sales reported on SEC form 4 over the last 10years. Awards, option exercises, gifts and other non-market form 4 activity are excluded. Chart markers group a day's filings by direction; the table lists each filing.