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| Role | Insider | Date | Transaction | Value | Shares |
|---|---|---|---|---|---|
| Director | PAKIANATHAN DEEPIKA | Jan 27, 2023 | Sell | $46.36K | 120,161 |
| Director | PAKIANATHAN DEEPIKA | Jan 27, 2023 | Sell | $452.16 | 1,172 |
| Director | Orford Keith | Nov 11, 2021 | Sell | $42.41K | 48,190 |
| SR. VP, DEVELOPMENT | Molineaux Christopher | Nov 10, 2021 | Buy | $84.67K | 100,000 |
| Director | DRACHMAN JONATHAN G | Nov 10, 2021 | Buy | $171.9K | 200,000 |
| CEO | Molineaux Susan | Nov 10, 2021 | Buy | $84.67K | 100,000 |
| Director | Orford Keith | Nov 10, 2021 | Sell | $25.7K | 30,000 |
| Director | Orford Keith | Nov 9, 2021 | Sell | $43.52K | 51,810 |
| Chief Medical Officer | Orford Keith | Dec 16, 2020 | Sell | $14.68K | 2,447 |
| 10% Owner | BVF PARTNERS L P/IL | May 21, 2020 | Sell | $6.16M | 1,027,016 |
| 10% Owner | BVF PARTNERS L P/IL | May 21, 2020 | Sell | $6.39M | 1,064,332 |
| 10% Owner | BVF PARTNERS L P/IL | May 21, 2020 | Sell | $1.15M | 192,250 |
| SR. VP, FINANCE & SECRETARY | Wong Stephanie | Apr 15, 2020 | Sell | $40K | 5,000 |
| Chief Medical Officer | Orford Keith | Feb 20, 2020 | Sell | $24.17K | 3,021 |
| Chief Medical Officer | Orford Keith | Dec 23, 2019 | Sell | $18.13K | 3,021 |
| 10% Owner | BVF PARTNERS L P/IL | Nov 20, 2019 | Buy | $385.36K | 98,518 |
| 10% Owner | BVF PARTNERS L P/IL | Nov 20, 2019 | Buy | $310.13K | 79,285 |
| 10% Owner | BVF PARTNERS L P/IL | Nov 20, 2019 | Buy | $55.35K | 14,151 |
| 10% Owner | BVF PARTNERS L P/IL | Nov 14, 2019 | Buy | $240.94K | 71,495 |
| 10% Owner | BVF PARTNERS L P/IL | Nov 14, 2019 | Buy | $154.64K | 45,888 |
| 10% Owner | BVF PARTNERS L P/IL | Nov 14, 2019 | Buy | $37.42K | 11,105 |
| 10% Owner | BVF PARTNERS L P/IL | Oct 30, 2019 | Buy | $1.1M | 408,592 |
| 10% Owner | BVF PARTNERS L P/IL | Oct 30, 2019 | Buy | $893.83K | 331,048 |
| 10% Owner | BVF PARTNERS L P/IL | Oct 30, 2019 | Buy | $156.24K | 57,868 |
| 10% Owner | BVF PARTNERS L P/IL | Oct 29, 2019 | Buy | $2.27M | 872,373 |
Open-market purchases and sales reported on SEC form 4 over the last 10years. Awards, option exercises, gifts and other non-market form 4 activity are excluded. Chart markers group a day's filings by direction; the table lists each filing.