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| Role | Insider | Date | Transaction | Value | Shares |
|---|---|---|---|---|---|
| Director | TOPOREK MICHAEL | Mar 7, 2025 | Buy | $167K | 41,750 |
| CEO | Lipman Matthew E. | Mar 7, 2025 | Buy | $167K | 41,750 |
| Director | Strout Gordon Lewis Jr | Mar 7, 2025 | Buy | $166K | 41,500 |
| 10% Owner | SUBIN NEIL S | Dec 21, 2018 | Sell | $10.71K | 206,000 |
| 10% Owner | SUBIN NEIL S | Dec 21, 2018 | Buy | $5.36K | 103,000 |
| 10% Owner | MILLER LLOYD I III | Oct 5, 2017 | Sell | $6K | 100,000 |
| Insider | BVF PARTNERS L P/IL | Jul 14, 2017 | Sell | $239.62K | 3,993,637 |
| Insider | BVF PARTNERS L P/IL | Jul 14, 2017 | Sell | $14.53K | 242,236 |
| Insider | BVF PARTNERS L P/IL | Jul 14, 2017 | Sell | $6.34K | 105,713 |
| CFO | TAEGER LESLIE M | Jan 4, 2017 | Buy | $3.5K | 50,000 |
| 10% Owner | MILLER LLOYD I III | Dec 16, 2016 | Sell | $1.56K | 38,967 |
| 10% Owner | MILLER LLOYD I III | Dec 15, 2016 | Sell | $800 | 20,000 |
Open-market purchases and sales reported on SEC form 4 over the last 10years. Awards, option exercises, gifts and other non-market form 4 activity are excluded. Chart markers group a day's filings by direction; the table lists each filing.