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| Role | Insider | Date | Transaction | Value | Shares |
|---|---|---|---|---|---|
| Director | Thomas Stephen Basil | Sep 15, 2026 | Sell | $1.37M | 100,000 |
| CEO | Brennan Aoife | Jun 29, 2026 | Sell | $406.98K | 30,902 |
| Director | Thomas Stephen Basil | Feb 26, 2026 | Sell | $114.29K | 16,313 |
| Director | Thomas Stephen Basil | Feb 25, 2026 | Sell | $235.96K | 33,687 |
| Director | Thomas Stephen Basil | Feb 13, 2026 | Sell | $58.14K | 10,000 |
| Director | Thomas Stephen Basil | Feb 12, 2026 | Sell | $470.99K | 90,000 |
| Director | RA CAPITAL MANAGEMENT, L.P. | Jan 5, 2026 | Buy | $24.89K | 7,111 |
| Director | RA CAPITAL MANAGEMENT, L.P. | Dec 12, 2025 | Buy | $290.18K | 101,462 |
| Director | RA CAPITAL MANAGEMENT, L.P. | Dec 11, 2025 | Buy | $464.56K | 213,099 |
| CEO | Brennan Aoife | Jun 30, 2025 | Sell | $25.15K | 20,618 |
| SVP, Finance & CAO | Pimblett Emily | Jun 20, 2025 | Sell | $1.54K | 1,242 |
| SVP, Finance & CAO | Pimblett Emily | Mar 20, 2025 | Sell | $1.57K | 1,199 |
| CHIEF ACCOUNTING OFFICER | Pimblett Emily | Dec 19, 2024 | Sell | $2.49K | 1,235 |
| CHIEF ACCOUNTING OFFICER | Pimblett Emily | Sep 20, 2024 | Sell | $9.67K | 1,182 |
| CHIEF ACCOUNTING OFFICER | Pimblett Emily | Sep 20, 2024 | Sell | $72.54 | 9 |
| EVP, R&D AND CSO | Morisset Valerie | Jul 22, 2024 | Sell | $314.77K | 39,005 |
| EVP, R&D AND CSO | Morisset Valerie | Jul 22, 2024 | Sell | $239.4K | 30,000 |
| EVP, R&D AND CSO | Morisset Valerie | Jul 19, 2024 | Sell | $72.33K | 10,201 |
| EVP, R&D AND CSO | Morisset Valerie | Jul 19, 2024 | Sell | $362K | 50,000 |
| EVP, R&D AND CSO | Morisset Valerie | Jul 18, 2024 | Sell | $267.33K | 38,576 |
| EVP, R&D AND CSO | Morisset Valerie | Jul 17, 2024 | Sell | $22.16K | 3,207 |
| EVP, R&D AND CSO | Morisset Valerie | Jul 16, 2024 | Sell | $356.5K | 50,000 |
| EVP, R&D AND CSO | Morisset Valerie | Jul 15, 2024 | Sell | $297.06K | 42,377 |
| EVP, R&D AND CSO | Morisset Valerie | Jul 12, 2024 | Sell | $353.5K | 50,000 |
| EVP, R&D AND CSO | Morisset Valerie | Jul 11, 2024 | Sell | $355.5K | 50,000 |
Open-market purchases and sales reported on SEC form 4 over the last 10years. Awards, option exercises, gifts and other non-market form 4 activity are excluded. Chart markers group a day's filings by direction; the table lists each filing.