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| Role | Insider | Date | Transaction | Value | Shares |
|---|---|---|---|---|---|
| Director | Freund John Gordon | May 18, 2026 | Sell | $681 | 20 |
| Director | Freund John Gordon | May 15, 2026 | Sell | $142.55K | 4,127 |
| Director | Lurker Nancy | May 13, 2026 | Sell | $161.86K | 4,500 |
| Director | BOHLIN GAREN G | May 11, 2026 | Sell | $323.49K | 8,700 |
| EVP & General Counsel | Dieter David | Mar 18, 2026 | Sell | $488.1K | 13,976 |
| EVP & General Counsel | Dieter David | Mar 9, 2026 | Sell | $228.11K | 6,224 |
| EVP & Chief Commercial Officer | Dreyer Scott | Mar 3, 2026 | Sell | $1.87M | 46,417 |
| EVP & Chief Commercial Officer | Dreyer Scott | Mar 3, 2026 | Sell | $145.88K | 3,559 |
| EVP & Chief Commercial Officer | Dreyer Scott | Dec 8, 2025 | Sell | $532.77K | 11,125 |
| EVP & Chief Commercial Officer | Dreyer Scott | Dec 8, 2025 | Sell | $315.08K | 6,475 |
| Director | Balice-Gordon Rita J. | Dec 5, 2025 | Sell | $171.67K | 3,650 |
| Director | Fallon John A. | Nov 12, 2025 | Sell | $1.65M | 34,853 |
| CFO | Tupper Colleen | Nov 6, 2025 | Sell | $1.02M | 25,142 |
| CFO | Tupper Colleen | Nov 6, 2025 | Sell | $200.52K | 4,858 |
| EVP and Chief Medical Officer | Smith Thomas B | Aug 29, 2025 | Sell | $671.58K | 17,478 |
| EVP & Chief Commercial Officer | Dreyer Scott | Aug 18, 2025 | Sell | $626.17K | 16,389 |
| Director | SANTINI GINO | Aug 15, 2025 | Sell | $201.02K | 5,405 |
| 10% Owner | Rubric Capital Management LP | Aug 13, 2025 | Sell | $946.25K | 25,000 |
| EVP & Chief Commercial Officer | Dreyer Scott | Aug 13, 2025 | Sell | $184.88K | 4,861 |
| Director | Freund John Gordon | Aug 8, 2025 | Sell | $400.64K | 11,659 |
| Director | Freund John Gordon | Jun 9, 2025 | Sell | $202.15K | 6,601 |
| CFO | Tupper Colleen | Mar 21, 2025 | Sell | $192.07K | 6,396 |
| EVP & Chief Commercial Officer | Dreyer Scott | Mar 21, 2025 | Sell | $566.98K | 18,881 |
| CFO | Tupper Colleen | Mar 20, 2025 | Sell | $36.18K | 1,206 |
| EVP & Chief Commercial Officer | Dreyer Scott | Mar 20, 2025 | Sell | $57.81K | 1,927 |
Open-market purchases and sales reported on SEC form 4 over the last 10years. Awards, option exercises, gifts and other non-market form 4 activity are excluded. Chart markers group a day's filings by direction; the table lists each filing.
