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| Role | Insider | Date | Transaction | Value | Shares |
|---|---|---|---|---|---|
| Principal Accounting Officer | Lally Robert B | Jul 17, 2026 | Sell | $8.14K | 1,525 |
| Principal Accounting Officer | Lally Robert B | Jul 16, 2026 | Sell | $9.19K | 1,671 |
| Director | ORBIMED ADVISORS LLC | Apr 14, 2026 | Buy | - | 336,603 |
| Director | Bonita David P | Apr 14, 2026 | Buy | - | 336,603 |
| Director | Bonita David P | Apr 14, 2026 | Buy | - | 384,689 |
| Director | ORBIMED ADVISORS LLC | Apr 14, 2026 | Buy | - | 384,689 |
| Director | SLATTERY JOSEPH P | Dec 24, 2025 | Buy | $95.84K | 16,000 |
| Director | Stampacchia Otello | Jul 25, 2025 | Buy | $8M | 267,556 |
| Director | Bonita David P | Jul 25, 2025 | Buy | $2.5M | 83,611 |
| Director | ORBIMED ADVISORS LLC | Jun 24, 2022 | Buy | $288.27K | 65,965 |
| Director | Bonita David P | Jun 24, 2022 | Buy | $288.27K | 65,965 |
| Director | Bonita David P | Jun 24, 2022 | Buy | $515.71K | 96,035 |
| Director | ORBIMED ADVISORS LLC | Jun 24, 2022 | Buy | $515.71K | 96,035 |
| Director | ORBIMED ADVISORS LLC | Jun 23, 2022 | Buy | $86.88K | 23,419 |
| Director | Bonita David P | Jun 23, 2022 | Buy | $86.88K | 23,419 |
| Director | Bonita David P | Jun 22, 2022 | Buy | $237.16K | 66,806 |
| Director | ORBIMED ADVISORS LLC | Jun 22, 2022 | Buy | $237.16K | 66,806 |
| Chief Scientific Officer | Zhang Xiaoyan Michelle | Jan 11, 2022 | Sell | $11.57K | 964 |
| Chief Scientific Officer | Zhang Xiaoyan Michelle | Jan 10, 2022 | Sell | $432 | 36 |
| Director | FORMELA JEAN FRANCOIS | Dec 14, 2021 | Sell | $83.43K | 5,959 |
| 10% Owner | Atlas Venture Fund XI, L.P. | Dec 14, 2021 | Sell | $83.43K | 5,959 |
| Director | FORMELA JEAN FRANCOIS | Dec 13, 2021 | Sell | $121.95K | 8,330 |
| 10% Owner | Atlas Venture Fund XI, L.P. | Dec 13, 2021 | Sell | $121.95K | 8,330 |
| Director | FORMELA JEAN FRANCOIS | Dec 10, 2021 | Sell | $180.19K | 11,989 |
| Chief Scientific Officer | Zhang Xiaoyan Michelle | Dec 10, 2021 | Sell | $14.76K | 1,000 |
Open-market purchases and sales reported on SEC form 4 over the last 10years. Awards, option exercises, gifts and other non-market form 4 activity are excluded. Chart markers group a day's filings by direction; the table lists each filing.