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| Role | Insider | Date | Transaction | Value | Shares |
|---|---|---|---|---|---|
| CEO | Frohlich Tom | May 16, 2025 | Buy | $44.4K | 6,000 |
| Director | RA CAPITAL MANAGEMENT, L.P. | Jun 17, 2024 | Buy | $1.55M | 928,110 |
| SEE REMARKS | Eldridge George A | Jun 14, 2024 | Sell | $375.45K | 15,000 |
| CHIEF TECHNICAL OFFICER | Verwijs Marinus | Jun 14, 2024 | Sell | $265K | 10,600 |
| CHIEF MEDICAL OFFICER | Gillies Hunter | Jun 13, 2024 | Sell | $147K | 6,000 |
| CHIEF MEDICAL OFFICER | Gillies Hunter | May 17, 2024 | Sell | $82.45K | 3,914 |
| CHIEF MEDICAL OFFICER | Gillies Hunter | May 17, 2024 | Sell | $1.88K | 86 |
| CEO | NOYES TIMOTHY P | May 16, 2024 | Sell | $187.41K | 8,707 |
| CEO | NOYES TIMOTHY P | May 16, 2024 | Sell | $28.35K | 1,293 |
| CHIEF TECHNICAL OFFICER | Verwijs Marinus | May 2, 2024 | Sell | $41.63K | 1,981 |
| CEO | NOYES TIMOTHY P | May 1, 2024 | Sell | $183.79K | 9,035 |
| CEO | NOYES TIMOTHY P | May 1, 2024 | Sell | $20.14K | 965 |
| CEO | NOYES TIMOTHY P | May 1, 2024 | Sell | $27.02K | 1,357 |
| SEE REMARKS | Dake Benjamin T | Apr 17, 2024 | Sell | $143.87K | 6,447 |
| CHIEF MEDICAL OFFICER | Gillies Hunter | Apr 17, 2024 | Sell | $82.27K | 3,689 |
| SEE REMARKS | Dake Benjamin T | Apr 17, 2024 | Sell | $7.83K | 338 |
| CHIEF MEDICAL OFFICER | Gillies Hunter | Apr 17, 2024 | Sell | $7.25K | 311 |
| SEE REMARKS | Dake Benjamin T | Apr 17, 2024 | Sell | $1.63K | 68 |
| CEO | NOYES TIMOTHY P | Apr 16, 2024 | Sell | $109.56K | 4,491 |
| CEO | NOYES TIMOTHY P | Apr 16, 2024 | Sell | $137.41K | 5,509 |
| SEE REMARKS | Eldridge George A | Apr 10, 2024 | Sell | $180.14K | 6,729 |
| SEE REMARKS | Eldridge George A | Apr 10, 2024 | Sell | $21.25K | 771 |
| Director | GRAYZEL DAVID S. | Apr 9, 2024 | Sell | $334.48K | 11,882 |
| CHIEF TECHNICAL OFFICER | Verwijs Marinus | Apr 1, 2024 | Sell | $109.58K | 3,796 |
| SEE REMARKS | Eldridge George A | Apr 1, 2024 | Sell | $390.21K | 12,495 |
Open-market purchases and sales reported on SEC form 4 over the last 10years. Awards, option exercises, gifts and other non-market form 4 activity are excluded. Chart markers group a day's filings by direction; the table lists each filing.
