Best Investments/trading ideas for the weekJoin our free webinar on September23,2026.

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Best Investments/trading ideas for the weekJoin our free webinar on September23,2026.

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| Role | Insider | Date | Transaction | Value | Shares |
|---|---|---|---|---|---|
| 10% Owner | Opaleye Management Inc. | May 1, 2026 | Sell | $162.41K | 10,081 |
| 10% Owner | Opaleye Management Inc. | May 1, 2026 | Sell | $8.06K | 500 |
| 10% Owner | Opaleye Management Inc. | Apr 30, 2026 | Sell | $387.62K | 24,000 |
| 10% Owner | Opaleye Management Inc. | Apr 30, 2026 | Sell | $16.15K | 1,000 |
| 10% Owner | Opaleye Management Inc. | Apr 29, 2026 | Sell | $402.9K | 23,360 |
| 10% Owner | Opaleye Management Inc. | Apr 29, 2026 | Sell | $17.25K | 1,000 |
| 10% Owner | Opaleye Management Inc. | Apr 28, 2026 | Sell | $808.65K | 43,788 |
| 10% Owner | Opaleye Management Inc. | Apr 28, 2026 | Sell | $46.17K | 2,500 |
| 10% Owner | Opaleye Management Inc. | Apr 21, 2026 | Sell | $4.14K | 202 |
| 10% Owner | Opaleye Management Inc. | Apr 17, 2026 | Sell | $230.54K | 11,267 |
| 10% Owner | Opaleye Management Inc. | Apr 17, 2026 | Sell | $102.31K | 5,000 |
| Insider | MANCHESTER MANAGEMENT CO LLC | Dec 12, 2025 | Sell | $136.79K | 6,500 |
| Insider | MANCHESTER MANAGEMENT CO LLC | Dec 11, 2025 | Sell | $422.28K | 13,500 |
| Insider | MANCHESTER MANAGEMENT CO LLC | Dec 10, 2025 | Sell | $262.13K | 8,625 |
| Insider | MANCHESTER MANAGEMENT CO LLC | Dec 10, 2025 | Sell | $262.13K | 8,625 |
| Insider | MANCHESTER MANAGEMENT CO LLC | Dec 9, 2025 | Sell | $268.68K | 8,785 |
| Insider | MANCHESTER MANAGEMENT CO LLC | Dec 9, 2025 | Sell | $268.68K | 8,785 |
| Insider | MANCHESTER MANAGEMENT CO LLC | Dec 8, 2025 | Sell | $3.86M | 125,400 |
| Insider | MANCHESTER MANAGEMENT CO LLC | Dec 8, 2025 | Sell | $3.86M | 125,400 |
| Insider | MANCHESTER MANAGEMENT CO LLC | Dec 8, 2025 | Sell | $63.2K | 2,000 |
| Insider | MANCHESTER MANAGEMENT CO LLC | Dec 8, 2025 | Sell | $63.2K | 2,000 |
| 10% Owner | Opaleye Management Inc. | Oct 6, 2025 | Buy | $38.36K | 1,267 |
| Chief Operating Officer | Stegagno Peter | Jun 5, 2025 | Sell | $51.6K | 1,862 |
| Chief Sci. and Tech. Officer | Cioanta Iulian | May 15, 2025 | Sell | $114.99K | 3,639 |
| 10% Owner | Opaleye Management Inc. | Apr 29, 2025 | Buy | $127.45K | 5,000 |
Open-market purchases and sales reported on SEC form 4 over the last 10years. Awards, option exercises, gifts and other non-market form 4 activity are excluded. Chart markers group a day's filings by direction; the table lists each filing.